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Tepezza’s targeted IGF-1R inhibition sets a new standard in Graves’ Ophthalmopathy, driving rapid adoption and billion-dollar sales.
AUSTIN, TX, UNITED STATES, August 11, 2025 /EINPresswire.com/ — Amgen’s Tepezza (teprotumumab-trbw) has rapidly emerged as a groundbreaking therapy in the Graves’ Ophthalmopathy (also known as Thyroid Eye Disease, or TED) treatment landscape, reshaping clinical standards and expanding commercial potential globally. Approved by the U.S. FDA in January 2020, Tepezza became the first and only targeted biologic therapy indicated for TED, offering a transformative solution for a condition that previously relied on non-specific treatments like corticosteroids, orbital radiation, or invasive surgery. Tepezza’s approval was backed by robust OPTIC Phase III trial data, which showed that over 80% of patients experienced significant proptosis reduction, a key measure of eye bulging caused by TED.
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Tepezza has since experienced rapid uptake, achieving blockbuster status with annual global revenues surpassing more than a billion in 2024 alone. Its success can be attributed to its targeted mechanism of action, blocking the insulin-like growth factor-1 receptor (IGF-1R), which plays a critical role in TED pathophysiology. Following Amgen’s acquisition of Horizon Therapeutics in 2023, the company has aggressively expanded Tepezza’s reach, investing in global market access, regulatory filings, and next-generation administration forms, including subcutaneous delivery, now in late-stage trials.
Market Dynamics:
The Graves ophthalmopathy treatment market is undergoing a transformative shift, driven by the introduction and success of Tepezza (teprotumumab-trbw), the first and only FDA-approved targeted biologic for Thyroid Eye Disease (TED). Tepezza has redefined the standard of care by addressing the root cause of the disease through IGF-1R inhibition, offering significant improvements in proptosis, diplopia, and inflammation that conventional therapies failed to deliver consistently. This innovation has created a new therapeutic class, altering the dynamics of a previously underserved market and paving the way for biologic dominance in autoimmune ophthalmology.
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Market Size:
DataM Intelligence anticipates that the global Graves ophthalmopathy treatment market will grow at a CAGR of 4.2%, reaching US$ 3.01 billion from US$ 2.09 billion in 2024.
Major Companies:
Major companies working towards the market’s growth include Amgen Inc., Immunovant, Inc., Viridian Therapeutics, Inc., Argenx, Tourmaline Bio, Inc., F. Hoffmann-La Roche Ltd, Sling Therapeutics and among others.
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